Today we presented a patient with menorrhagia and bruising concerning for primary homeostasis problem (=PLATELETS). We discussed different symptoms of primary vs secondary homeostasis. She was diagnosed with Acute Promyelocytic Leukemia and treated with ATRA and Arsenic Trioxide (ATO).
Take home points:
- Identify differences in presentation of thrombocytopenia versus coagulation disorders
- Recognize causes of thrombocytopenia
- Acute leukemias usually present with symptoms of pancytopenia
- APL is distinct amongst leukemias in pathophysiology and treatment