Recruitment lecture 10.11.2019

Today we had a patient with unremarkable PMH presenting with jaundice. LFTs were in the 1000s, a clinical scenario with limited DDx. They ultimately had liver biopsy and diagnosed with autoimmune hepatitis.

Take home points:

  • Pale/grey stools and dark urine are associated with conjugated (and not unconjugated) hyperbilirubinemia with narrower DDx
  • AST/ALT > 1,000 has a limited differential, including drug-induced liver injury, autoimmune hepatitis, and viral hepatitis
  • Recognize the types of autoimmune hepatitis (including DIAH and overlap syndromes) with their associated antibodies and different prognosis / treatment

 

Some more information can be found here AAH – 10.11

 

AS

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out /  Change )

Google photo

You are commenting using your Google account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s